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Vitamin B 12 ( CYANOCOBALAMIN )

It is also known as extrinsic factor of castle. It is a water-soluble vitamin.

In 1948 Smith and Parker isolated cyanocobalamin from the liver. In 1955 its complex structure was determined.

It is a complex organo-metallic compound with a cobalt atom. Vitamin B12 cooperates with folate in the synthesis of DNA, so deficiency of either leads to megaloblastosis.

It contains cobalt, therefore it is also known as cobalamin. It is mainly synthesised by bacteria and is found primarily in meat, eggs and dairy products. There has been considerable research into proposed plant sources of vitamin B12. Fermented Soya products, seaweeds, and algae such as spirulina have all been suggested as containing significant B12. However, the present consensus is that any B12 present in plant foods is likely to be unavailable to humans and so these foods should not be relied upon as safe sources. Vitamin B12 is necessary for the synthesis of red blood cells, the maintenance of the nervous system, and growth and development in children. Deficiency can cause anemia. Vitamin B12 neuropathy, involving the degeneration of nerve fibres and irreversible neurological damage, can also occur.


Sources of vitamin B12

Good sources are liver, kidney, meat, fish, eggs, milk and cheese.

Vitamin B12 is not found in foods of vegetable origin. Bacteria in colon also synthesize it. Unlike folic acid, vitamin B12 is heat stable. Liver is the main storage site of vitamin B12. About 2 mg are stored in the liver and another 2 mg elsewhere in the body. These stores are sufficient to fight against any deficiency for one to three years.

Good sources of vitamin B12 for vegetarians are dairy products or free-range eggs. ½ pint of milk (full fat or semi skimmed) contains 1.2 µg. A slice of vegetarian cheddar cheese (40g) contains 0.5 µg. A boiled egg contains 0.7 µg. Fermentation in the manufacture of yoghurt destroys much of the B12 present. Boiling milk can also destroy much of the B12.

Vegetarians are advised that they should ensure their diet includes foods fortified with vitamin B12. A range of B12 fortified foods are available. These include yeast extracts, Vecon vegetable stock, veggie burger mixes, textured vegetable protein, Soya milks, vegetable and sunflower margarines, and breakfast cereals.

This vitamin is found in the fungus Streptomyces griseus. Hence vitamin B12 is obtained as a by-product in the manufacture of Streptomycin.

Absorption takes place from the ileum. Intrinsic factor present in the normal gastric juice is essential for the proper absorption of vitamin B12. It is stored in the liver. From the liver it passes to the bone marrow and helps in the maturation of the red cells. Vitamin B12 is excreted in the faeces and urine.

Benefits of vitamin B12

Essential for the formation and maturation of red blood cells. Vitamin B12 is Castle’s extrinsic factor, which combines with the intrinsic factor present in the normal gastric juice and is absorbed. B12 is necessary for the rapid synthesis of DNA during cell division. This is especially important in tissues where cells are dividing rapidly, particularly the bone marrow tissues responsible for red blood cell formation. If B12 deficiency occurs, DNA production is interrupted and abnormal cells called megaloblasts occur. This results in anaemia. Symptoms include excessive tiredness, breathlessness, listlessness, pallor, and poor resistance to infection. Other symptoms can include a smooth, sore tongue and menstrual disorders. Anaemia may also be due to folic acid deficiency, folic acid also being necessary for DNA synthesis.

It increases the white cell count and the platelets through its action in the bone marrow.

Concerned with the maintenance of normal health and activity of certain parts of the nervous system. Vitamin B12 not only cures the pernicious anaemia, but also the neurological manifestations of pernicious anaemia, e.g. sub acute combined degeneration of the spinal cord.

Formation of lipid from carbohydrate in influenced by vitamin B12. Hyperglycemia due to vitamin B12 deficiency can be corrected after administration of vitamin B12.

It also maintains the integrity of the epithelial cells especially of the mouth and the stomach.

It favors the normal growth and is particularly useful in premature babies: the action is probably due to an adequate absorption of metabolic products by influencing the intrinsic factor of Castle formed in the gastric mucous membrane.

It is essential for maintaining the functional integrity of the myelinated fibres of the central nervous system and the peripheral nerves.

It happens to correct or prevent fatty infiltration of the liver by favoring formation of methionine and protecting the liver from injury by certain toxic agents.

Deficiency signs

Due to deficiency of vitamin B12 pernicious or macrocytic or megaloblastic anaemia is produced.

Its deficiency also causes hyperglycemia.

Growth is retarded, nervousness and irritability is also observed.

Deficiency might occur as a result of lack in diet, lack of intrinsic factor as in pernicious anaemia, defective absorption due to intestinal disease, infection with microorganisms, which have affinity for vitamin B12 and thus destroy it in the intestinal tract.

Other important features in vitamin B12 deficiency in man are mucosal atrophy and inflammation of tongue, mouth etc., degenerative lesions of the posterior and lateral columns of the spinal cord. The patient may feel pain, tingling and numbness in the extremities and there may be partial paralysis.

Dietary deficiency of vitamin B12 occurs in subjects who are strict vegetarians and eat no animal products.

Daily requirement:

The requirement is very small.

a) Normal adults 1mcg

b) Pregnancy 1.5 mcg

c) Lactation 1.5 mcg

d) Infants and children 0.2 mcg


 

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Comment Script

Comments

Vitamin B12 dosage
I have a question on B-12,how much should one take on a daily bases. They sell it in 500 mcg or 1000 mcg ?
#1 - marie chase - 10/01/2007 - 11:15
10-8-07
I've been taking high doses of B-12 for neuropathy in my feet (I am not a diabetic). Can I take too much?
#2 - Carol - 10/08/2007 - 07:41
Vitamin B 12 deficiency
I am not a vegetarian and I am B12 deficient and now take 1000mcg by shots, apparently you can't get too much because you excrete what you don't need. I would very much like to know what organisims are likely to destroy the b12 in the illium of the digestive tract? Are there probiotics that can correct any imbalance? Are there tests that can be done to ensure that my digestive tract has a healthy flora?
Thanks
and by the way it is an extremely painful and fatigue causing disorder.
#3 - SD - 11/08/2007 - 16:32
I HAVE BEEN TAKING 2500 MCG. OF SUBLINGUAL B12 FOR A MONTH NOW. I AM DIABETIC. I AM NOW NOTICING A LOT OF TINGLING & PAIN IN MY FEET. I DIDN'T HAVE THIS BEFORE. I STARTED TAKING THE B-12 FOR ENERGY, WHICH HELPED A LOT. BUT, I BELIEVE THIS AMOUNT OF B12 IS TOO MUCH FOR MY BODY, & CAUSING ADVERSE SYMPTOMS.
#4 - LYNN - 12/01/2007 - 15:22
I have been taking vitamin B-12, 2000 units. I have noticed that I have been breaking out on my face and on my scalp. Could this be possible, am I taking too much of the vitamin?
#5 - Joey - 01/08/2008 - 15:03
I have a Colostomy and have been experiencing a lot of raw irritation around the stoma. I have recently been put on B-12 and am curious as to if it contains acid.
#6 - cheri - 02/04/2008 - 23:38
i am a 46yr old lady,suffering terrabily with b12 deficiency, im so depressed and the fatigued, not been able to work for 3months, in fear of loosing my job that i enjoy, i have just got up tp having my b12 injections monthly but finding this to long, as im good for nothing by week 3. my doctor insists i have my injections 4 weekly then every 3 months, i will never cope with that, its having a big inpact on my life, is there any help out there, i feel so alone with it all. be gratefull for any help. thanks
#7 - julie - 02/14/2008 - 08:41
Julie, you can obtain 1000 mcg/ml of vitamin b12 in Canada OTC for about $2 an amp. you can visit 77canadapharmacy.com and have them ship the b12 to you from Canada to the USA if you are located in the USA. I questioned them on the legality of the issue and they said they have never had any problems and delivery is between 2-9 days to the states. You dont have to suffer, you can administer it yourself, no big deal.
#8 - Mark - 02/28/2008 - 13:10
I have been suffering from Megaloblastic Anaemia and have had B12 shots for 10 days.I stopped the shots one week ago.My HB has returned to 13 but had blood transfusion on two occasions before.. The blood film shows normal cells but platelets have gone abnormally high.White blood cells level is 5.9 and in the normal range. I still suffer from inflammation of my tongue and atrophy of the stomach.Will these symptoms subside with time or I must investigate my stomach problem.

Thanks
#9 - Roshan - 03/22/2008 - 04:33
i am suffering from def of vit b12 amd my brain does not work fluently.plz help me.
#10 - mayur - 03/23/2008 - 05:28
As reported there is very little chance of hypervitaminosis with B 12. Doctors previously believed that injection of B 12 was necessary to correct the deficiency of this vitamin. But a scientific study published in 2003 from Holland showed that oral supplementation is as good. I read that at least 1000-2000 mcg daily oral supplement is necessary for deficiency correction.
#11 - robi - 03/24/2008 - 14:26
I HAVE A B-12 DEFICIENTCY AND HAVE BEEN GETTING A DOUBLE DOSE OF B-12 INJECTIONS FOR 8 WEEKS. STOPPED FOR 2 WEEKS AND HAVE BUZZING IN MY SPINE ALONG WITH EXTREME WEAKNESS IN LEGS.BACK ON THE INJECTIONS 1X A WEEK. IS THIS ENOUGH ,I READ ABOUT SUBACUTE DEG.OF THE SPINE AND IM AFRAID OF PERMENANT DAMAGE.
#12 - LISA - 04/03/2008 - 07:33
I was put on B12 injections and came out in painful spots all over my face and scalp - it is not unheard of, especially with injections. My dr told me to stop having the injections immediately.

I'm going to try B12 supplements in tablet form I think. I suspect I have a problem with absorbing it though.
#13 - cwright - 04/08/2008 - 10:03
I am a type 2 diabetic and a kidney cancer survivor...only 70% of my right kidney is functioning ...I had a total left kidney removed due to cancer in 1991...I feel tired and off balance sometimes...how much B-12 should i take daily ? or weekly ?

Cynthia m - 6/05/08
#14 - Cynthia - 06/05/2008 - 16:19
I recently had blood work done and my B12 level was 1040 and the range is 200-1100. Could I become out of range, and if so, what would my symtoms be ?



#15 - Gail - 07/19/2008 - 22:43
I am anemic and have been taking 2500 mcg sublingual b12 daily for energy. Worked for a while but lately I can barely function in the afternoon b/c I am so lethargic. Any suggestions would be helpful. I need to get my energy back!
#16 - Jodi - 08/06/2008 - 22:12
I have noticed that my mood fluctuates in different intervals especially when I stop taking B12 Viltamin. For your information, I am taking one tab of multivitamine (Vitamins and Minerals) every day and feels excellent. So, can you please advise if there is any side effects for b12 and multi vitamin and can I take it for the whole life. I am in my 52 years and feeling good and strong. Your recommendations and advise will be highly appreciated.
#17 - barakat obeidat - 08/19/2008 - 01:26
I gave my 95 year old aunt a 3000mcg sublingual B-12 tablet yesterday to see if it would help her dementia/ Alzheimer's. It's to soon to tell about the dementia but I think it has helped her post herpetic neuralgia, but now her leg [thigh] hurts. I'm trying to decide on whether to give her another tablet. I'll keep tabs and see what happens. I'll update here when I have more information.
#18 - Michele - 9/02/2008 - 09/02/2008 - 17:19
I started taking vitamin b12 daily a multi vitamin with 25mcg and a additional tablet with 1000mcg. Is this way overboard, please advise
THANKS
#19 - JOHN A - 09/30/2008 - 19:40
does the canadian pharmacy you spoke about to Julie on 2-28-08 require a prepscription? i'm having the same problem as she is. My GP is 'afraid of giving me too much' !He absolutely refuses to give me more than x1 a wk. I'm a Celiac patient with fibro and Chronic Fatigue. I feel the effects of my wkly injection sort of running out at about 3 days after the injection. I barely make it to the following wk. Can barely navigate. I KNOW I should have at least 2 injections a week! But I doubt he'll give me a prescription for more than he's already written....x1 a wk.
#20 - Mark #8 - 10/28/2008 - 19:18
can you take 2 much vitamin B-12 ?
#21 - Gail Shelton - 11/14/2008 - 10:21
I have been taking B12 1200 mg, slow release tablets. I have noticed that I have become itchy with red lumps on my back, arms my face and head, and naturally I scratch them. Would this be a side effect of B12?
#22 - Liz - 12/04/2008 - 12:06
I was put on B12 to assist with tinitus. It didn't change anything in that regard. But I think I actually feel a little better in general being a person prone to anemia and excessive bleeding. Are there side effects to B12 or is it ok to self subscribe it?
#23 - Karen - 12/13/2008 - 09:32
can vitamin B12 help with tingling neuropathy & numbness in your hands?
#24 - Donna Peretz - 12/24/2008 - 15:46
I had blood work the same day I got a shot. My B12 was 8000.
Now much later with no shots it is 333. Is this acceptable or is it on low side? I asked my Dr to do the MMA urine test but no results yet.
#25 - Annie - 01/01/2009 - 11:20
i am 56 years old and have been told i have celiac disease
all blood work came bac normal except B-12 is low normal.

I was told to take 2000 mcg. daily. If I follow this how long
will it take before I feel better?

I am very tired most of the time, I have tingling in back of
head on occasion and also down my back, light headed,
depressed, nausea, etc.
#26 - Vesta - 01/26/2009 - 10:57
I take 2500 sublingual tabs daily. I have broken out in red bumps on nceck, chest and back area. Can this be a side effect?
#27 - Lynn Lollis - 02/02/2009 - 21:17
if i order the b12 injections, how do i know how much to injected weekly???
#28 - care - 02/16/2009 - 18:02
My doctor started me on B 12 injections once a month for 6 months to start. I have Neuropathy of both legs and also I had H-Pylori infection with Gastritis in the stomach which would not allow the B 12 tablets to be absorbed into the intestines. The Nurse Practitioner at the office says they are now giving B 12 injections to people with Dementia.
#29 - Louis - 02/20/2009 - 01:48
is vit b 12 def associated with nuckle pigmentation??????
#30 - bharat - 04/02/2009 - 00:59
Please warn your readers that any acid suppression Rx like prilosec - nexium - etc. will block the absorbption of B-12. Stomach acid is needed to assist metabolize the vitamin. If you let the condition go without testing your B-12 level you can end up with permanent peripheral neuropathy in your feet and it is a very painful and usually permanent condition that can disable you. Other common risk factors that exacerbate the neropathy are low thyroid hormone and diabetes.

I wanted to ask - I take 2500 mcg daily sublingual and want to switch to an IM. Can you advise what IM dose size and concentration of B-12 would equal my current PO dose. Can the IM dose be injected biweekly, and if so how may CC and concentration.

Regards,

Reply to: lastvintage@yahoo.com
#31 - Clayton - 04/22/2009 - 18:43
I there former paient of the Dr bernstein he gives b6 and b12 injections . I was diong fine on the program with no symtoms however I as have started giving them to myself I am now experiencing tingling of legs, arms ans miner chest discomfort what am I doing wrog I did not experience this on the Bernstein program!
#32 - Maylene - 05/02/2009 - 15:17
im taking vitamin b1b6b12 for almost a week now...
i weight about 90kilograms and im just 21, my concerned is if these medication would certainly inrease my weight?
i need your immediate response...i would be very thankful if you do....
good day!
#33 - glenda - 05/06/2009 - 06:55
I recently had vitamind B12 lab done to check my levels. It came back 495. I want to start giving myself B12 injections again. I'm thinking of starting at 1 cc once a week till my numbers get a little higher, and my energy level has improved. I can barely 'function' lately.
#34 - Jan - 05/10/2009 - 20:48
Can you take too much B-12.
#35 - John - 05/17/2009 - 13:27
What is equivalent to 1 mcg? I need to know how many mg that is.
#36 - Suzanne Baisch - 05/26/2009 - 19:59
I have bells palsy and heard b12 will help. Any suggestions?
#37 - Lisa - 05/31/2009 - 22:10
Hi i was recently diagnosed with b12 deficiency- my reading was 144 and was told that 195-615 is a normal range and i am now taking 1000mg of b12 a day orally along with a multi vitamin- can i take more than that?
Will this affect my weight?
#38 - Lynne - 06/08/2009 - 12:56
I was just found out I have a B12 deficiency. I tried OTC B complex like the doc ask. All it did was make me quite sick at my stomach, so now we are going to try the injections 1xmonthly. Did not realize that this was what was making me so tired and even not sleep well. Do yo think that this will help?
#39 - Sherry - 06/24/2009 - 16:55
i take 1000mcg or tr b12 dailey for extreme fatigue. i have been diagnosed with cfs, bi polar, and fibromyalgia. i have no energy and get out of breath easily. is this too much b12 to take? are there benefits to taking the time release fomula? how long before i notice any benefit in energy, if i do at all?
#40 - jennifer - 06/24/2009 - 22:30
1000mcg is equal to 1mg
#41 - charlotte - 07/02/2009 - 10:10
i have just foundout that i have vit 12 b deficiencymy reading was 154 i was started on vit b12 inj once a month 1cc to start with i thank i need it more often how much do i need
#42 - max hudson - 07/04/2009 - 16:43
Liquid B12 with Folic Acid form under the tongue turned my B12 deficiency around in short order; I read that pill form is destroyed in by stomach acid; the only better method of B12 distribution is the shot. Highly recommend liquid B12 with Folic Acid

Liquid B12 from Vitamin Shoppe is a mild delicious fruit flavored
Liquid B12 from GNC is nasty flavored

Also get your Vitamin D level check!
#43 - Karen - 09/12/2009 - 20:02
I have discus hernia. Presently I am taking B12-500mcg per day. B1 - 250mg per day and B1 - 20mg pre day. Is that OK or should I change something? Thanks!
#44 - moma - 09/13/2009 - 04:02
I have neuropathy and I'm not diebetic. The nerves in my feet are so bad I really want to cut off my feet. I need to know how much b-12 could possibly help. Anyone with the same problems help!!! Please before I go out of my mind! Thanks
#45 - Linda 10-15-09 - 10/14/2009 - 21:04
I, too, have fibro (20 years now). Also have Celiac Disease. I take 1cc twice weekly. The nurse in my GP's office taught me how to give my own injections. It may take a while for you to notice any difference, if your levels are very low. Your body can usually 'tell' you when you're feeling better, you won't be so fatigued. Due to my GI probs, the oral B12 isn't as effective for me. I wish you luck.
#46 - Jennifer - 11/06/2009 - 19:57
I just finish chemo after 6months and now i am feeling very tired short breath and dont want to eat I am vegetarian Can B12 help and how much must i use Please help
#47 - theresa - 11/09/2009 - 14:12
can you turn me on to a forum of people who are or have taken vit. b1 and why are they taking and what are the benefits, or the down side of it. thanks
#48 - charlotte - 11/30/2009 - 12:21
I suffer from PBC and have just been told that I have B12 deficiency and anemia, but I thought they were the same thing. my doctor has prescribed cyanocobalamin B12 and ferrous sulphate with ascorbic acid, but I'm concerned that the ferrous sulphate and the ascorbic acid will stop the B12 from working. I'd like someone elses opinion, as my doctor often gets it wrong, I've had to ring them back on numerous occassions because of the wrong dossage ect.
#49 - Isabella - 12/01/2009 - 08:18
I just took a b-12, 250 mcg. The other guy in here said there was only 500/100 CVS has 250...Your Welcome Thanx
#50 - Tired lol - 12/09/2009 - 06:41
I am 47, healthy, and take 2500 mcg of B-12. I am also a vegetarian. What's the best amount to take? Thanks.
#51 - Ana. - 12/15/2009 - 14:25
I submitted the comment above, but I forgot to say that I am female and take the 2500 mcg DAILY. I don't take anything else except a calcium/magnesium supplement, and I regularly exercise. Thanks for any advice.
#52 - Ana. - 12/15/2009 - 14:30
go on trivita.com i buy sublingual b12 with folic acid it really does the body good... they have other good products too check them out...
#53 - aliyah - 12/17/2009 - 15:51
ordered 1000mcg B12 to inject. how much can be injected weekly or bi-weekly...is it supose to be 1cc?
#54 - sdl - 01/08/2010 - 14:34
ordered 1000mcg B12 to inject. how much can be injected weekly or bi-weekly...is it supose to be 1cc? is it different from the sublingual?
#55 - sdl - 01/08/2010 - 14:35
if not any health problem can i tale b-12 in prevantive majer?
#56 - hasmukhbhai - 01/11/2010 - 01:16
I am 64 yrs old and feel fatigue all day even i do not work.I feel numbness on feet and my fingers.Do I have b12 difficiency? what do I take?
#57 - aryon - 01/18/2010 - 03:28
I am a 55yrs old i was diagnosed with pernicious anemia in 1999 started V b12 injections in my right hip, after 1 yr i was experiencing burning in my right side and back, after 2 yrs it got worse i told my specialist i was given the injection in left hip, In 7 days I could not walk for 3 months. had shillings test done had injection in right arm, my hand is now clawed. i have not had b12 injections for 8yrs. i have just started sublingual b12 liquid and have had a reaction to it, what can i take, i'm desperate, I am severly deficient of b12.
#58 - delia - 02/04/2010 - 08:29
Suzanne 1mcg is a 1000mg
#59 - kriss - 02/05/2010 - 13:20
1 mcg is 1/1000th of a mg
#60 - SJ - 02/16/2010 - 14:46
People in internet forums should really consider talking to medical professionals instead of seeking advice on the internet. You never know where the advice is coming from. Medical practitioners have a vested interest in keeping you alive and as comfortable as possible. If you have a problem talk to another doctor or ask your doctor more questions.

Knowledge is power. I don't go to the elementary school to ask around about string theory physics.

My wife has several medical conditions and I am a biologist with extensive training yet we still follow Dr.s orders (albeit not blindly when something arises).
#61 - Use your resources - 02/23/2010 - 19:31
Kriss you have it reversed. 1 mcg(microgram) is 1/1000 of a gram, therefore 1,000 mcg = 1gram
#62 - richard - 03/30/2010 - 17:29
Vitamin B12 is only synthesized by Bacteria. Neither plants nor animals have the abilities to make it. The best source of B12 is nutritional yeast.
#63 - Ben - 04/01/2010 - 18:29
Hello delia,
There is solution for your B12 problem. In Greece we have a special doctor which heal with detoxification and herbs. She is pathology doctor but she turn to naturopathy medicine. She have a way to increase the B12 with herbs and not chemicals. You try contact with her and if you can try to come to cure you cause she may can heal your problems. Many people from aboard visit her and she help them and heal them.
Her name is Alexandra Efthimiadou and she is in north Greece in Thessaloniki city.
I will give you her office number.
0030 2310 228738.
I wish I helped enough. Get well soon.
Yota
#64 - Yota - 04/02/2010 - 19:25
I take 2500 mcg of vitamin b12 and about 1000 mg of folate daily for chronic fatigue syndrome. I feel great! I am thinking to take for a month. Then I will cut in half! Is anyone thinks this is too much? Please let me know. Thanks in advance!
#65 - ragae - 04/09/2010 - 23:03
can any body tell me what to eat and drink.
with b12 deficincy
#66 - lynsey - 04/16/2010 - 06:37
Lynsey, it depends on what kind of b12 deficiency you have, if you have pernicious anaemia it doesn't really matter what you eat because your stomach cannot get the b12 out of the meat or vitamine pills you take because of a lack of intrinsic factor. You should not try to use b12 supplements before you have your blood tested because these supplements will give wrong test indications.
Normally, if you have b12 deficiency it is not fixed by using supplements for a while, you need to continue your doses.

The normal doses for pernicious anaemia or Addisons-Biermer decease is the first 10 doses, 1 each week or at least you have to wait three days before taking another dose. Then slowly build it to minimal one dose each two months. But if you have severe neurological problems you should have one dose each week for a time period of two years and then slowly build it to one each two months. But for some people two months is to long so you need to look what is the right interval for you.

Another think you should have tested are B6, B11, Iron which are all connected. Another think that is wise to test is TSH, T3, T4 and FT4, for a thyroid disease which also are often connected with b12 deficiency.

But one thing you should never do is take B11 supplements if you are not taking B12 supplements, B11 supplements strengthen the neurological effects of B12 deficiency.

Hope this was helpful for you
#67 - Marco - 04/27/2010 - 17:13
thank you

marco it was verry helpfull.
#68 - lynsey - 04/29/2010 - 12:49
I hate fish oils
#69 - Fish oils - 04/30/2010 - 04:31
I have a 14 year son with vitiligo. i heard B12 1000 mcg is good for that condition. what do you advice. and also Folic Acid 800 mcgThanks
#70 - Elaine - 05/13/2010 - 11:33
Yes I have also read that, the combination of 1mg B12 and 2x5mg B11 (Folic Acid) and for at least 3 months and in combination with sun exposure.

A study shows that 64 out of a 100 patients the expansion of Vitiligo stopped and 56% had signs of repigmentation and 6 out of the 100 patients recovered fully.

There is an great article about that:

Juhlin L, Olsson MJ. (1997) "Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure.". Acta Derm Venereol, jrg.77 (nr.6): pp. 460-462. PMID 9394983

But always contact your Physician before you start a treatment.
#71 - Marco - 05/14/2010 - 12:40
I am b-12 low(170) Pills of any kind make me sick to stomach,dizzy and tired,have tried all brands and liquid afraid shot will do worse ,any one have any suggestion I am so scared?
#72 - shirley - 06/18/2010 - 17:22
If you have Anaemia pills won't work. Before taking some shots contact your Physician. But shot help, it will take a couple of weeks for some to notice the difference. But if you take shots you should not stop after a couple of weeks when you feel fine, it will go back to the low value.

I would just try it, and don't be scared it cannot hurt you, but just in case check if you are not allergic to some of the ingredients.

#73 - Marco - 06/20/2010 - 10:59
I was diagnosed with F.A.P.in 2005 and had my Colon removed in 2006 i now have a J-pouch, i have just found out that as well as being anemic i now have vitimin 'b12 deficiency and have been perscribed Cyanocobalamin 50 mg. per day for 50 days to start with. I kept going to doctors with symptoms of headaches, tiredness, forgetfullness, sore tounge, depression, excessive heavy menstral, pain in legs and back, pins and needles and swollen legs. Also just started in a loss of appetite recently and always feeling thirsty. All doctors kept saying was that i was dehydrated because dehydration is one of the down sides when having colon removed and having to rely on medication to control bowel movements. (loperimide)

Advice is available online on what to eat to help build and keep b12 to good levels but it doesnt really say exact what cereals are good for this, any help would be much aopreciated.
#74 - Amanda - 07/16/2010 - 07:09
do taking probiotics orally help the absoption of vit b12?i do not want to take it parentally,i want to take it orally.i have severe deficiency.so please guide as to the factors helping the absoption.also let me know the foods n drugs hampering the absoption.
#75 - shama - 07/19/2010 - 02:44
My two daughters (25 and 23) and I (50) just had blood work done and had vitamin B12 levels of 150, 156 and 172 respectively. But we all have high levels of red blood cells, especially my 25 year old daughter, which was the reason she was sent to a hematologist in the first place and lead to this discovery. How does that happen? Everything I have read says we should be anemic. We have all been put on doxycycline because we were diagnosed with Lyme disease also. The internist has us getting routine B12 shots. My eldest daughter is getting hers more regularly because she had the strongest results for Lyme disease and is exhausted and studying to take the Bar in a week :( Is it harmful to have the shots when our red blood cell count is high or on the high side of normal? Any suggestions or has anyone heard of this happening before?
#76 - Sally - 07/20/2010 - 12:10
what is the average dose of b12 once a week
#77 - charlie royster - 07/21/2010 - 14:24
i m 23 years old i want to know is vit B12 deficiency related to hair loss.As i m vit B12 deficient and also suffering from extreme hair loss.plz suggest me its treatment ..plz help me
#78 - shika - 07/30/2010 - 04:48
kriss, and richard....i don't want to be rude but you should not post on dosage weight if you really do not know. it is dangerous and both of you are wrong 1microgram (mcg) is equal to 0.001milligrams (mg) you telling this woman that a gram isequivelent to 1 mcg is ridiculous and one would hope she doesn't listen to what she reads on a forum bc that much of a difference in dose could kill her if it were a different medication! i agree with post "use your references" this is full of misleading and inaccurate information talk to your doctor or call a clinic or look it up in a med book don't take "blogger" word for it. especially when it comes to your health
#79 - rn - 08/03/2010 - 08:30
Im 17 and im halfway through my injections, im starting to feel better but since i started my treatment ive had this terrible pain in my legs that just wont go, Is this normal?? xx
#80 - Lisa - 08/05/2010 - 15:48
B 12 GIVES YOU 3 HOUR WOODY AND YOU CAN PLAY CHESS AT SAME TIME0-:')
#81 - SPOOKY - 08/17/2010 - 13:32
is vitamin b12 2000 mcg a good sorce for weight loss.
#82 - chris - 08/29/2010 - 20:11
i was diagnosed with b12 defiency 5 years ago i only get 1000mg every 3 months i do not think that is enough as i experience numbness in my fingers but more in my feet a get a numb tongue which is quite frightening i am also so tired all the time i work 12 hour shifts in a nursing home i finish at 8 but have to be in bed for no later than 9 30 to make sure i can go ito work the next day i have no social life just sleeping the doctor tells me i am getting enough but i know my own body also i get massive bruises breaking out in different parts of my body help how much b12 injection is safe to take a month as i have found this website to buy my own injections as noone believes the way a feel not even my own doctor
#83 - elizabeth vance - 09/20/2010 - 15:31
Methlycobalamin is the best and most natural form of vitamin b12. The body does noe need to work to break it down because it is absorbed readily. Methylcobalamin provides methylation factors and is the only b12 I would take.
#84 - Patrick - 10/03/2010 - 08:17
B12 Cyanocobalamin is the synthetic form of B12. Methylcobalamin is the natural form... Cyano may be the cause of the side effects some are experiencing or the reason of no positive improvements.
#85 - Marie - 10/06/2010 - 10:38
I got a script from my MD and give hubby gives me a shot 1000mg every week. And I've had much improvements w/my ADHD, mental confusion (alzhemiers), and a host of other serve symptoms.
#86 - Marie - 10/06/2010 - 10:45
I have been taking B-12 shots which are 1000 mcg. One per month. How much liquid B-12 would you have to take (how many teaspoons) to get the same amount of B-12 as my shot has in it.
#87 - Mary - 10/12/2010 - 16:02
I am 70 and was recently suffering from light-headedness, fatigue, dizziness and frequent (one or 2 per minute) heart palpitations. I had a couple ECGs and a Sonogram and was told that my heart is fine and the palpitations are of no major concern and the other symptoms are likely old age. Well I was certainly not happy with that result and researched on the web and came across http://www.drugs.com/symptom-checker/. There one of the suggestions for my condition was a B12 deficiency. I got me 5mg sublingual methylcobolamine pills daily and noticed a significant improvement within days and was completely symptom free within 3 weeks. No more palpitations, no more fatique.
#88 - Robby - 10/27/2010 - 23:53
what is the correct amount of B-12 a person should take?
#89 - ANita - 10/28/2010 - 13:51
Great information on all the vitamin b12 benefits. Preventing deficiency is a must it seems!
#90 - John - 11/17/2010 - 23:41
To the person who said to not consult the internet for info. I just want to say that sometimes that's all you have to go on. Especially when your own doctor(like in my case) doesn't know what's wrong and could care less in looking into it. no one seems to know why i'm having all these problems with my nerves and I just found out I have low Vitamin B12(209 and then 1 month and half later it dropped to 187) and I EAT meat. So any ideas...since the doctors don't have a clue
#91 - Linda - 11/22/2010 - 01:09
I completely agree with Linda. I have struggled for 3 years with strange symptoms. Of course since the doctors, would not, could not, come up with a diagnosis until I found 1 physician who is a cracker jack. Boy, was he tough for me to find but I was referred to him by a phlebotomist of all people in the medical profession. He found out that I had an abnormal weakness on the right side of my body. Then sent to a neurologist who referred me to a neurosurgeon and needed an operation to remove spinal cord compression. Otherwise, I was considered mentally ill. You see it is so much easier to call someone mentally deficient than to take the time and interest in diagnosing. If people understood that their primary care physician will give you 5 minutes in his office and he is supposed to diagnose you and if the blood work does not meet a deficiency you are mentally ill. I spent 28 years in a great industry, top in sales in an engineering/sales capacity and then was diagnosed with Bipolar. What!!!!!!!!! Ok, I'll give you physicians the benefit of the doubt. However, what are my bipolar symptoms. They certainly are not the typical symptoms. ie bleeding from my throat. Throat pain. Bone pain. Acid Reflux. Ok, if this is bipolar, maybe I am stupid enough to believe it. Simple, they tag you with a disorder such as this and you are screwed. However, the cracker jack doctor put me on Prednisone and this certainly helped with pain and guess what my throat bleeding has almost been reduced to mininal occurrences. If I have bipolar I should have freaked out being on Prednisone. No freakouts occurred at all. It has actually helped sleeping problems and correcting spinal pain to a tolerable level. I fought for years with hypothyroidism since I was 29, I am now 52. The fatigue never went away. Three weeks ago, my specialist physician who happens to be fabulous is still trying to find out what my problem is. He has thrown everything at me even the kitchen sink to figure out my problem. He thinks Ankylosing Spondylitis, however I doubt this diagnosis. He wrote a script for B-12. GUESS WHAT! For the first time in years almost decades I felt like a normal human being. No more loss of balance, significant decrease in foot burning and pain for which I was presribed neurotin. Neuroting did help. However, I notice after this first B-12 shot I started noticing less pain in the feet amazingly and my appetiite and nausea improved incredibly. OK, what is going on here? Do the doctors care to work with you until they find an answer? NO, most could care less. I have learned this myself and watched my mother suffer until she died do to barely mediocre care from the medical profession. Sarah Palin talked about death camps with medicare. This always existed for the ill. This is not new, Sarah. Her behavior and so called intelligence thinks she stumbled on something new with Obama Care. This always existed. Mininmal care for the elderly as they cripple the financial system of Medicare with great health issues. Unless you are wealthy watch out! Only the wealthy get the best care as I know this from my Grandparents who retired from Merck & Company and they still received the fabulous healthcare plans from Merck when they retired. Grandmother died at 93. Her husband is still alive after being diagnosed with tongue cancer FIVE years ago. Take heed America! Push your physicians if there is a physical problem you know your body. They do not! And do they care? Well, you answer that question. If you are financially secure with a great health insurance you are excluded from this. As you are the fortunate and this does not apply. But, if you have lousy insurance and are currently not employed you are just a pest to the medical profession. So, Linda I believe you are quite correct. NO, the internet is not the way to diagnose yourself but there are many people out there without any kind of medical insurance. The gravely unfortunate. So after struggling for many years with various strange symptoms and a multitude of dangerous drug treatments I find vitamin B-12 helped me after methotrexate, Plaquinel and many other drugs. I mean really Vitamin B12 that we think is innocuous and really insignificant works! Nothing else helped the way B-12 did. A month ago I would have said you have got to be kidding. I was not told I was B-12 deficient and really don't think it was significantly low. But my platelet count keeps dropping and I have had bleeding from the throat until I was put on Prednisone which reduced the bleeding significantly. Come on. Something is wrong and I went through so many scopes and tests. The kicker is I was put on large doses of Prilosec and other Gerd medications which stop the absorption of B-12. Eureka! Maybe there is a clue there. Well, time to get off my soapbox. Yes, something as simple as B-12 helped me significantly. I can tell that the B-12 is waning at this point and will need to continue the shot and for the person on this site fearful of taking the innoculation, I say, I have so many allergies to drugs, food etc. I had absolutely no problems whatsoever taking the shot! Try it. I put my neck out thinking the preservative may trigger an allergic reaction it did not at all. If you are missing Intrinsic Factor this is the only way you can take the B-12. I will be seeing hematologist to look further into this. We also have a history of Chrons disease they also said I have IBD. You think they would have put some of these other disorders together and think maybe they could have put this all together. ICD10 is supposed to help capture all of our medical records to be reviewed and the doctors do not read them thoroughly like my one physician did. Ok, physicians, stop discriminating who you are going to help and follow your Hippocratic Oath. I think a lot of Physicians spent a good amount of time partying during their education while in medical school. This is frightening. I have seen and went through such hideous care by some medical facilities that I could write a book. Remember the book, Drs. Can Be Hazardous to Your Health, now I know why the book was written. When I was young I would have never believed this. Use Caution with the medical profession. Can be very frightening out there.
#92 - Dee - 11/29/2010 - 16:38
i am suffering from B12 deficiency.what tablet to take?I live in jakarta,indonesia.
#93 - anupama - 12/03/2010 - 02:01
I ALWAYS GET PAIN DURING SLEEPING HRS
#94 - SCSharma - 12/12/2010 - 08:45
Now I'm confused.
#95 - Cam - 01/05/2011 - 06:32
Thank you, Dee... Well said. Here I sit with the same symtoms as everyone else.. I can tell I have trouble with concentration. I have a Thyroid Condition, then developted High Blood Pressure. Then 5 years ago I developed Diabetes. My blood tests indicate low B12. Then, through research AND the Internet, I find out low levels of Vitamin B12 cause Stomach Polyps. My last endoscopy almost 2 years ago indicated I have numerous stomach polyps. Yet I can't find out what the normal range of B12. Depending on what doctor you ask, it can be anywhere from 500 to 1200. Does anyone out there know what the normal range should be?
#96 - Adriana - 01/06/2011 - 01:44
I currently take prevacid every day. Would it work to switch to taking prevacid every other day and taking a b12 vitamin on the days i dont take prevacid? Also, anyone have any ideas for managing the gerd symptoms sans the typical b12 inhibiting part. Ive heard eating a few almonds before meals helps....
#97 - Lisa - 01/07/2011 - 23:53
#45 Linda I have the same no diabetes etc but b12 was low have started b12 injections 6mos ago. This whole process started 3years ago but no one could figuere out was going on with my feet the pain at times like you say is so bad you want to cut them off, I have found that keeping my feet cool and wearing flip flops helps a great deal, so I ice my feet all night long with little ice packs its been three years and finally the pain is subsiding somewhat without the drugs they wanted to prescribe(gabapentene anti siezure drug) As well I get b12 shots 1x month I think that this may be helping as well finally. Good Luck
#98 - Tina - 02/01/2011 - 13:10
I just got liquid B12 from GNC and have been on it for 2 days now. I took the regular dosage that it says on the bottle which is 1mcg. I want to know if you can take this everyday or is that overdosing? I know I'm low in B12 but I don't want to take too much.
#99 - Tabitha - 02/06/2011 - 20:20
ASK YOUR DOCTORS!!
#100 - Flats - 02/13/2011 - 08:11
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